| 1. Round | 27/08/1978 | FC Twente '65 | - | PEC Zwolle | 1:1 | ||||
| 2. Round | 30/08/1978 | FC Utrecht | - | FC Twente '65 | 1:1 | ||||
| 3. Round | 02/09/1978 | MVV | - | FC Twente '65 | 0:0 | ||||
| 20. Round | 06/09/1978 | FC Twente '65 | - | MVV | 3:0 | ||||
| 4. Round | 09/09/1978 | SC NEC | - | FC Twente '65 | 0:0 | ||||
| 5. Round | 17/09/1978 | FC Twente '65 | - | Sparta Rotterdam | 2:1 | ||||
| 6. Round | 24/09/1978 | FC Den Haag | - | FC Twente '65 | 0:0 | ||||
| 7. Round | 01/10/1978 | FC Twente '65 | - | AZ '67 Alkmaar | 4:2 | ||||
| 8. Round | 08/10/1978 | HFC Haarlem | - | FC Twente '65 | 2:2 | ||||
| 9. Round | 21/10/1978 | FC Twente '65 | - | Go Ahead Eagles | 1:2 |  |
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| 10. Round | 28/10/1978 | PSV Eindhoven | - | FC Twente '65 | 1:0 | ||||
| 11. Round | 04/11/1978 | FC Twente '65 | - | FC VVV | 2:0 | ||||
| 12. Round | 11/11/1978 | ACV Vitesse | - | FC Twente '65 | 3:2 | ||||
| 13. Round | 25/11/1978 | FC Twente '65 | - | Feyenoord | 0:0 | ||||
| 14. Round | 02/12/1978 | Roda JC Kerkrade | - | FC Twente '65 | 0:0 | ||||
| 15. Round | 09/12/1978 | FC Twente '65 | - | FC Volendam | 3:0 | ||||
| 17. Round | 16/12/1978 | FC Twente '65 | - | AFC Ajax | 2:3 |
Netherlands