| 1. Round | 22/08/2020 | Desna Chernigov | - | Zorya Lugansk | 3:1 |  |
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| 2. Round | 11/09/2020 | Dinamo Kiev | - | Desna Chernigov | 0:0 | ||||
| 3. Round | 19/09/2020 | Inhulets Petrove | - | Desna Chernigov | 1:1 | ||||
| 4. Round | 27/09/2020 | Desna Chernigov | - | Rukh Lviv | 3:1 | |
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| 5. Round | 04/10/2020 | Desna Chernigov | - | Shakhtar Donetsk | 2:2 | ||||
| 8. Round | 31/10/2020 | FK Oleksandriya | - | Desna Chernigov | 2:2 | |
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| 9. Round | 07/11/2020 | Desna Chernigov | - | FC Mynai | 1:0 | |
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| 10. Round | 22/11/2020 | Desna Chernigov | - | FK Lviv | 0:1 | ||||
| 11. Round | 29/11/2020 | Kolos Kovalivka | - | Desna Chernigov | 1:1 | |
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| 12. Round | 06/12/2020 | Desna Chernigov | - | Vorskla Poltava | 1:0 | ||||
| 13. Round | 13/12/2020 | Desna Chernigov | - | FK Mariupol | 2:0 | ||||
| 14. Round | 13/02/2021 | Zorya Lugansk | - | Desna Chernigov | 2:1 | |
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| 15. Round | 21/02/2021 | Desna Chernigov | - | Dinamo Kiev | 1:1 | |
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| 16. Round | 26/02/2021 | Desna Chernigov | - | Inhulets Petrove | 3:0 | ||||
| 17. Round | 08/03/2021 | Rukh Lviv | - | Desna Chernigov | 0:4 | |
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| 19. Round | 20/03/2021 | Desna Chernigov | - | SK Dnipro-1 | 0:2 |
Ukraine