| 1. Round | 23/02/2025 | St. Louis City SC | - | Colorado Rapids | 0:0 | ||||
| 2. Round | 02/03/2025 | Colorado Rapids | - | FC Dallas | 3:3 |  |
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| 3. Round | 09/03/2025 | Austin FC | - | Colorado Rapids | 0:1 | |
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| 4. Round | 16/03/2025 | San Jose Earthquakes | - | Colorado Rapids | 1:2 | ||||
| 5. Round | 23/03/2025 | Colorado Rapids | - | Portland Timbers | 0:3 | ||||
| 6. Round | 29/03/2025 | Colorado Rapids | - | Charlotte FC | 2:0 | ||||
| 7. Round | 06/04/2025 | Vancouver Whitecaps | - | Colorado Rapids | 2:0 | ||||
| 8. Round | 13/04/2025 | Colorado Rapids | - | San Diego FC | 3:2 | |
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| 9. Round | 20/04/2025 | Houston Dynamo | - | Colorado Rapids | 2:2 | |
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| 10. Round | 27/04/2025 | Colorado Rapids | - | Seattle Sounders | 1:1 | ||||
| 11. Round | 04/05/2025 | D.C. United | - | Colorado Rapids | 2:1 | ||||
| 12. Round | 11/05/2025 | Colorado Rapids | - | San Jose Earthquakes | 0:2 |
Brazil