| 5. Round | 13/10/2021 | Deportivo Dongu | - | Lobos ULMX | 2:2 | ||||
| 6. Round | 18/10/2021 | Lobos ULMX | - | Cañoneros FC | 2:3 |  |
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| 8. Round | 31/10/2021 | Lobos ULMX | - | Escorpiones | 1:3 |  |
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| 9. Round | 06/11/2021 | Cafetaleros de Chiapas | - | Lobos ULMX | 1:2 | ||||
| 10. Round | 11/11/2021 | Lobos ULMX | - | CD Zap | 1:2 | ||||
| 11. Round | 13/11/2021 | Inter de Querétaro | - | Lobos ULMX | 1:1 | ||||
| 12. Round | 21/11/2021 | Lobos ULMX | - | Montañeses FC | 3:2 | ||||
| 13. Round | 27/11/2021 | Leviatán FC | - | Lobos ULMX | 1:4 | |
Mexico