| 1. Round | 20/07/2021 | Godoy Cruz | - | Rosario Central | 2:1 |  |
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| 2. Round | 25/07/2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 5. Round | 06/08/2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 10. Round | 05/09/2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Round | 15/09/2021 | Banfield | - | Rosario Central | 1:2 | ||||
| 19. Round | 31/10/2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 |
Argentina