| 1. Round | 09/01/2021 | CF América [U17] | - | Atlético San Luis [U17] | 3:1 |  |
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| 2. Round | 16/01/2021 | CF Monterrey [U17] | - | CF América [U17] | 2:0 | |
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| 3. Round | 22/01/2021 | CF América [U17] | - | FC Juárez [U17] | 2:1 | ||||
| 4. Round | 31/01/2021 | Santos Laguna [U17] | - | CF América [U17] | 4:2 | ||||
| 5. Round | 06/02/2021 | CF América [U17] | - | Puebla FC [U17] | 1:2 | |
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| 6. Round | 13/02/2021 | CF América [U17] | - | Gallos Blancos [U17] | 1:2 | ||||
| 7. Round | 20/02/2021 | Atlas Guadalajara [U17] | - | CF América [U17] | 3:1 | ||||
| 8. Round | 27/02/2021 | CF América [U17] | - | CF Pachuca [U17] | 0:3 | |
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| 9. Round | 03/03/2021 | Club Tijuana [U17] | - | CF América [U17] | 4:0 | ||||
| 11. Round | 14/03/2021 | Deportivo Guadalajara [U17] | - | CF América [U17] | 3:0 | ||||
| 13. Round | 03/04/2021 | CF América [U17] | - | Club Necaxa [U17] | 1:2 | ||||
| 14. Round | 10/04/2021 | UANL Tigres [U17] | - | CF América [U17] | 3:3 | ||||
| 15. Round | 17/04/2021 | CF América [U17] | - | Cruz Azul [U17] | 0:2 | ||||
| 16. Round | 25/04/2021 | Deportivo Toluca [U17] | - | CF América [U17] | 3:0 | ||||
| 17. Round | 01/05/2021 | Pumas UNAM [U17] | - | CF América [U17] | 8:2 |
USA
Mexico