| 2. Round | 08/07/2022 | Mazatlán FC [U18] | - | UANL Tigres [U18] | 1:0 | ||||
| 3. Round | 18/07/2022 | CF Pachuca [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 4. Round | 22/07/2022 | Mazatlán FC [U18] | - | Atlético San Luis [U18] | 4:1 |  |
|||
| 5. Round | 27/07/2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 2:0 |  |
|||
| 9. Round | 16/08/2022 | Mazatlán FC [U18] | - | Gallos Blancos [U18] | 3:1 | ||||
| 10. Round | 19/08/2022 | FC Juárez [U18] | - | Mazatlán FC [U18] | 2:1 | ||||
| 11. Round | 26/08/2022 | Mazatlán FC [U18] | - | CF América [U18] | 3:0 | |
|||
| 12. Round | 03/09/2022 | CF Monterrey [U18] | - | Mazatlán FC [U18] | 0:0 | ||||
| 13. Round | 07/09/2022 | Mazatlán FC [U18] | - | Atlas Guadalajara [U18] | 1:4 | |
|||
| 14. Round | 11/09/2022 | Cruz Azul [U18] | - | Mazatlán FC [U18] | 3:3 | ||||
| 15. Round | 16/09/2022 | Mazatlán FC [U18] | - | Deportivo Toluca [U18] | 4:1 | |
|||
| 16. Round | 24/09/2022 | Club Necaxa [U18] | - | Mazatlán FC [U18] | 1:2 | |
|||
| 8. Round | 27/09/2022 | Club León [U18] | - | Mazatlán FC [U18] | 2:2 | |
|||
| 17. Round | 02/10/2022 | Santos Laguna [U18] | - | Mazatlán FC [U18] | 2:1 |
Mexico