| 1. Round | 28/07/2020 | Atlético San Luis | - | FC Juárez | 1:1 | ||||
| 2. Round | 02/08/2020 | Deportivo Toluca | - | Atlético San Luis | 3:2 | ||||
| 3. Round | 10/08/2020 | Atlético San Luis | - | Atlas Guadalajara | 1:1 |  |
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| 4. Round | 13/08/2020 | Club Tijuana | - | Atlético San Luis | 0:2 |  |
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| 5. Round | 15/08/2020 | Deportivo Guadalajara | - | Atlético San Luis | 2:1 | |
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| 6. Round | 24/08/2020 | Atlético San Luis | - | Cruz Azul | 1:3 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | |
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| 8. Round | 04/09/2020 | CF Pachuca | - | Atlético San Luis | 3:1 | |
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| 9. Round | 08/09/2020 | Atlético San Luis | - | Club Necaxa | 2:1 | |
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| 10. Round | 13/09/2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 12. Round | 27/09/2020 | Atlético San Luis | - | Club León | 0:2 |  |
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| 14. Round | 16/10/2020 | Atlético San Luis | - | Gallos Blancos | 2:1 | |
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| 15. Round | 26/10/2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 30/10/2020 | Atlético San Luis | - | Mazatlán FC | 0:5 |
Argentina
Chile