| 1. Round | 12/02/2021 | Rosario Central II | - | Argentinos Juniors II | 0:0 | ||||
| 2. Round | 19/02/2021 | River Plate II | - | Rosario Central II | 1:1 | ||||
| 3. Round | 26/02/2021 | Rosario Central II | - | Godoy Cruz II | 1:1 | ||||
| 4. Round | 05/03/2021 | Racing Club II | - | Rosario Central II | 2:1 | ||||
| 5. Round | 12/03/2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 6. Round | 19/03/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:0 | ||||
| 7. Round | 26/03/2021 | Rosario Central II | - | Central Córdoba SdE II | 3:1 | ||||
| 8. Round | 02/04/2021 | San Lorenzo II | - | Rosario Central II | 0:0 | ||||
| 9. Round | 09/04/2021 | Rosario Central II | - | Banfield II | 1:1 | ||||
| 10. Round | 16/04/2021 | Aldosivi II | - | Rosario Central II | 1:3 | ||||
| 11. Round | 23/04/2021 | Rosario Central II | - | Estudiantes II | 1:3 | ||||
| 12. Round | 30/04/2021 | Rosario Central II | - | Newell's Old Boys II | 0:2 |
Argentina