| 1. Round | 11/09/2021 | Panathinaikos | - | Apollon Smyrnis | 4:0 | ||||
| 2. Round | 18/09/2021 | PAS Giannina | - | Panathinaikos | 1:0 | ||||
| 3. Round | 22/09/2021 | Aris Saloniki | - | Panathinaikos | 1:0 | ||||
| 4. Round | 26/09/2021 | Panathinaikos | - | Volos NFC | 5:1 | ||||
| 5. Round | 03/10/2021 | Olympiakos Piraeus | - | Panathinaikos | 0:0 |  |
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| 10. Round | 22/11/2021 | Lamia | - | Panathinaikos | 1:3 |  |
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| 16. Round | 05/01/2022 | Panathinaikos | - | Aris Saloniki | 2:0 | ||||
| 17. Round | 09/01/2022 | Volos NFC | - | Panathinaikos | 3:1 | ||||
| 20. Round | 29/01/2022 | Panathinaikos | - | Asteras Tripolis | 0:1 | ||||
| 21. Round | 02/02/2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
| 22. Round | 06/02/2022 | PAOK Saloniki | - | Panathinaikos | 2:1 |
Sweden
Nicaragua