| 1. Round | 07/01/2022 | Pumas Tabasco | - | CF Monterrey II | 0:1 | ||||
| 2. Round | 16/01/2022 | Leones Negros | - | Pumas Tabasco | 3:1 | ||||
| 3. Round | 20/01/2022 | Pumas Tabasco | - | TM Fútbol Club | 2:0 |  |
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| 4. Round | 26/01/2022 | Venados FC | - | Pumas Tabasco | 2:2 | |
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| 6. Round | 02/02/2022 | Pumas Tabasco | - | Club Celaya | 0:1 | ||||
| 7. Round | 09/02/2022 | Dorados de Sinaloa | - | Pumas Tabasco | 4:1 | ||||
| 8. Round | 17/02/2022 | Pumas Tabasco | - | Tapatío | 2:1 | |
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| 9. Round | 24/02/2022 | Atlante | - | Pumas Tabasco | 0:0 | ||||
| 10. Round | 03/03/2022 | Pumas Tabasco | - | Mineros de Zacatecas | 0:5 |
Mexico