| 1. Round | 24/07/2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 |  |
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| 6. Round | 29/08/2021 | FK Dinamo Makhachkala | - | Rotor-2 Volgograd | 2:0 | ||||
| 7. Round | 04/09/2021 | FK Tuapse | - | FK Dinamo Makhachkala | 0:1 | ||||
| 9. Round | 12/09/2021 | Dinamo Stavropol | - | FK Dinamo Makhachkala | 2:3 | ||||
| 10. Round | 18/09/2021 | FK Dinamo Makhachkala | - | Chernomorets Novorossisk | 3:0 | ||||
| 12. Round | 03/10/2021 | FK Dinamo Makhachkala | - | FK Biolog Novokubansk | 2:0 | ||||
| 17. Round | 07/11/2021 | Anzhi Makhachkala | - | FK Dinamo Makhachkala | 1:4 | ||||
| 18. Round | 13/11/2021 | FK Dinamo Makhachkala | - | Alania-2 Vladikavkaz | 3:0 | ||||
| 19. Round | 20/11/2021 | Kuban-Holding Pavlovskaya | - | FK Dinamo Makhachkala | 1:0 | ||||
| 24. Round | 03/04/2022 | FK SKA Rostov | - | FK Dinamo Makhachkala | 0:1 |
Russia