| 2. Round | 15/01/2022 | Deportivo Toluca [] | - | Club Necaxa [] | 2:1 | ||||
| 3. Round | 22/01/2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 |  |
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| 4. Round | 29/01/2022 | FC Juárez [] | - | Club Necaxa [] | 1:0 | ||||
| 5. Round | 05/02/2022 | Club Necaxa [] | - | Puebla FC [] | 4:0 | ||||
| 6. Round | 12/02/2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Round | 19/02/2022 | CF América [] | - | Club Necaxa [] | 3:3 | ||||
| 8. Round | 26/02/2022 | Club Necaxa [] | - | Gallos Blancos [] | 3:1 |
Mexico