| 2. Round | 12/02/2022 | Jorge Wilstermann | - | Blooming | 0:1 | ||||
| 3. Round | 20/02/2022 | Universitario de Vinto | - | Jorge Wilstermann | 2:0 | ||||
| 4. Round | 27/02/2022 | Jorge Wilstermann | - | Independiente Petrolero | 1:0 | ||||
| 5. Round | 06/03/2022 | Always Ready | - | Jorge Wilstermann | 0:0 | ||||
| 6. Round | 13/03/2022 | Club Aurora | - | Jorge Wilstermann | 1:0 | ||||
| 7. Round | 02/04/2022 | Jorge Wilstermann | - | Real Tomayapo | 1:2 | ||||
| 9. Round | 17/04/2022 | Jorge Wilstermann | - | Royal Pari | 2:2 | ||||
| 10. Round | 20/04/2022 | Blooming | - | Jorge Wilstermann | 3:3 | ||||
| 11. Round | 22/04/2022 | Jorge Wilstermann | - | Universitario de Vinto | 1:1 | ||||
| 12. Round | 01/05/2022 | Independiente Petrolero | - | Jorge Wilstermann | 3:2 |  |
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| 13. Round | 08/05/2022 | Jorge Wilstermann | - | Club Aurora | 0:0 | ||||
| 14. Round | 11/05/2022 | Jorge Wilstermann | - | Always Ready | 1:0 | ||||
| 15. Round | 15/05/2022 | Real Tomayapo | - | Jorge Wilstermann | 1:1 | ||||
| 16. Round | 22/05/2022 | Jorge Wilstermann | - | Bolívar | 1:4 | |
Bolivia