| 7. Round | 25/10/2021 | Cafetaleros de Chiapas | - | Sporting Canamy | 1:1 | ||||
| 8. Round | 30/10/2021 | Sporting Canamy | - | CD Zap | 0:1 | ||||
| 9. Round | 06/11/2021 | Inter de Querétaro | - | Sporting Canamy | 1:0 |  |
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| 10. Round | 10/11/2021 | Sporting Canamy | - | Montañeses FC | 2:1 | ||||
| 12. Round | 19/11/2021 | Inter Playa | - | Sporting Canamy | 7:1 | ||||
| 13. Round | 27/11/2021 | Sporting Canamy | - | Yalmakan FC | 0:3 |
Mexico