| 10. Round | 12/09/2020 | Club Necaxa | - | Deportivo Guadalajara | 1:2 | ||||
| 11. Round | 20/09/2020 | CF América | - | Deportivo Guadalajara | 1:0 | ||||
| 12. Round | 26/09/2020 | Deportivo Guadalajara | - | Mazatlán FC | 2:1 | ||||
| 13. Round | 05/10/2020 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | ||||
| 14. Round | 18/10/2020 | Deportivo Guadalajara | - | Atlas Guadalajara | 3:2 | ||||
| 15. Round | 25/10/2020 | Deportivo Guadalajara | - | Cruz Azul | 0:2 | ||||
| 16. Round | 01/11/2020 | Pumas UNAM | - | Deportivo Guadalajara | 2:2 | ||||
| 17. Round | 07/11/2020 | Deportivo Guadalajara | - | CF Monterrey | 3:1 |
Mexico