| 3. Round | 29/01/2022 | Tecos Fútbol Club | - | Leones Negros II | 1:1 | ||||
| 4. Round | 05/02/2022 | Leones Negros II | - | Colima FC | 1:2 | ||||
| 5. Round | 12/02/2022 | Leones Negros II | - | Correcaminos UAT II | 0:1 | ||||
| 6. Round | 19/02/2022 | Coras de Nayarit | - | Leones Negros II | 3:0 |  |
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| 7. Round | 26/02/2022 | Leones Negros II | - | Mineros de Fresnillo FC | 0:0 | ||||
| 9. Round | 12/03/2022 | Leones Negros II | - | Alacranes de Durango | 2:4 | ||||
| 1. Round | 07/04/2022 | Gavilanes de Matamoros | - | Leones Negros II | 2:2 |  |
Mexico