| 1. Round | 10/01/2003 | Real San Luis | - | Gallos Blancos (old) | 1:1 | ||||
| 2. Round | 18/01/2003 | Puebla FC | - | Real San Luis | 0:1 | ||||
| 3. Round | 24/01/2003 | Real San Luis | - | CF América | 0:4 |  |
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| 4. Round | 31/01/2003 | Jaguares Chiapas | - | Real San Luis | 3:1 | |
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| 5. Round | 08/02/2003 | Real San Luis | - | Cruz Azul | 2:2 | ||||
| 6. Round | 15/02/2003 | UAG Tecos | - | Real San Luis | 1:2 | |
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| 7. Round | 21/02/2003 | Real San Luis | - | UANL Tigres | 2:0 | ||||
| 8. Round | 01/03/2003 | CF Pachuca | - | Real San Luis | 2:2 | |
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| 9. Round | 07/03/2003 | Real San Luis | - | Deportivo Guadalajara | 0:2 | ||||
| 10. Round | 14/03/2003 | Atlético Cuernavaca | - | Real San Luis | 2:4 | ||||
| 11. Round | 22/03/2003 | Santos Laguna | - | Real San Luis | 2:0 | ||||
| 12. Round | 28/03/2003 | Real San Luis | - | Club Necaxa | 1:0 | ||||
| 13. Round | 05/04/2003 | Atlante | - | Real San Luis | 3:1 | ||||
| 14. Round | 11/04/2003 | Real San Luis | - | Monarcas Morelia | 2:4 | |
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| 15. Round | 19/04/2003 | Pumas UNAM | - | Real San Luis | 2:2 | |
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| 16. Round | 25/04/2003 | Real San Luis | - | Veracruz (old) | 0:3 | |
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| 18. Round | 09/05/2003 | Real San Luis | - | Deportivo Toluca | 2:3 | ||||
| 19. Round | 16/05/2003 | Atlas Guadalajara | - | Real San Luis | 1:1 | |
Mexico