| 1. Round | 12/01/2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 2. Round | 18/01/2025 | Club Necaxa | - | Deportivo Guadalajara | 3:2 | ||||
| 6. Round | 10/02/2025 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 11. Round | 09/03/2025 | Deportivo Guadalajara | - | CF América | 0:0 | ||||
| 12. Round | 16/03/2025 | FC Juárez | - | Deportivo Guadalajara | 1:1 | ||||
| 13. Round | 30/03/2025 | Deportivo Guadalajara | - | Cruz Azul | 0:1 | ||||
| 14. Round | 06/04/2025 | CF Monterrey | - | Deportivo Guadalajara | 3:1 | ||||
| 15. Round | 12/04/2025 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
| 16. Round | 16/04/2025 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 17. Round | 20/04/2025 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 |  |
Mexico