| 2. Round | 16/01/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 5:3 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 4. Round | 30/01/2021 | Deportivo Guadalajara [U20] | - | FC Juárez [U20] | 0:1 |  |
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| 5. Round | 08/02/2021 | Club León [U20] | - | Deportivo Guadalajara [U20] | 3:0 | |
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| 6. Round | 13/02/2021 | Deportivo Guadalajara [U20] | - | Club Necaxa [U20] | 1:0 | ||||
| 7. Round | 22/02/2021 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 3:2 | |
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| 9. Round | 03/03/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 10. Round | 06/03/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 11. Round | 14/03/2021 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | ||||
| 12. Round | 20/03/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 15. Round | 17/04/2021 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 16. Round | 24/04/2021 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 3:2 |
Mexico