| 2. Round | 16/01/2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 3. Round | 24/01/2021 | Deportivo Toluca | - | Club Necaxa | 2:0 | ||||
| 4. Round | 29/01/2021 | UANL Tigres | - | Club Necaxa | 1:1 |  |
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| 5. Round | 06/02/2021 | Club Necaxa | - | Cruz Azul | 0:2 | ||||
| 6. Round | 14/02/2021 | Deportivo Guadalajara | - | Club Necaxa | 2:2 | ||||
| 8. Round | 27/02/2021 | Puebla FC | - | Club Necaxa | 1:0 | ||||
| 13. Round | 04/04/2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 17. Round | 01/05/2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 |
Mexico