| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 2. Round | 12/01/2022 | Cancún FC | - | Club Celaya | 2:0 | ||||
| 4. Round | 26/01/2022 | Mineros de Zacatecas | - | Cancún FC | 1:0 |  |
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| 9. Round | 24/02/2022 | Cancún FC | - | CF Monterrey II | 0:0 | ||||
| 10. Round | 02/03/2022 | Correcaminos UAT | - | Cancún FC | 0:1 | ||||
| 11. Round | 09/03/2022 | Venados FC | - | Cancún FC | 1:0 | ||||
| 12. Round | 16/03/2022 | Cancún FC | - | Tapatío | 1:0 | ||||
| 14. Round | 26/03/2022 | Cancún FC | - | Pumas Tabasco | 2:2 |  |
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| 15. Round | 30/03/2022 | Cimarrones de Sonora | - | Cancún FC | 0:1 | ||||
| 16. Round | 07/04/2022 | Cancún FC | - | Coyotes de Tlaxcala | 1:0 | |
Mexico