| 3. Round | 22/01/2022 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 |  |
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| 4. Round | 06/02/2022 | Gallos Blancos | - | Puebla FC | 0:2 | |
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| 5. Round | 15/02/2022 | CF Pachuca | - | Gallos Blancos | 2:2 | ||||
| 7. Round | 25/02/2022 | Gallos Blancos | - | Deportivo Toluca | 1:1 | |
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| 14. Round | 17/04/2022 | Santos Laguna | - | Gallos Blancos | 1:1 | |
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| 15. Round | 22/04/2022 | Gallos Blancos | - | Cruz Azul | 0:1 | ||||
| 16. Round | 25/04/2022 | Club Tijuana | - | Gallos Blancos | 2:2 | ||||
| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 |
Mexico