| 2. Round | 22/01/2022 | Deportivo Dongu | - | Leviatán FC | 2:1 |  |
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| 5. Round | 12/02/2022 | Leviatán FC | - | Escorpiones | 1:5 | ||||
| 8. Round | 05/03/2022 | Inter de Querétaro | - | Leviatán FC | 2:2 | ||||
| 9. Round | 12/03/2022 | Leviatán FC | - | Montañeses FC | 0:4 | ||||
| 11. Round | 28/03/2022 | Sporting Canamy | - | Leviatán FC | 3:1 | ||||
| 12. Round | 02/04/2022 | Leviatán FC | - | Yalmakan FC | 1:3 | ||||
| 13. Round | 10/04/2022 | Lobos ULMX | - | Leviatán FC | 1:0 | |
Mexico