| 1. Round | 06/09/2020 | AFC Ajax [Women] | - | FC Twente [Women] | 3:1 | ||||
| 2. Round | 11/09/2020 | FC Twente [Women] | - | PEC Zwolle [Women] | 2:2 |  |
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| 3. Round | 02/10/2020 | SBV Excelsior [Women] | - | FC Twente [Women] | 0:3 | |
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| 4. Round | 11/10/2020 | FC Twente [Women] | - | ADO Den Haag [Women] | 0:2 | ||||
| 5. Round | 30/10/2020 | FC Twente [Women] | - | sc Heerenveen [Women] | 3:0 | |
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| 6. Round | 06/11/2020 | vv Alkmaar [Women] | - | FC Twente [Women] | 0:4 | |
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| 7. Round | 15/11/2020 | FC Twente [Women] | - | PSV Eindhoven [Women] | 3:2 | |
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| 8. Round | 22/11/2020 | FC Twente [Women] | - | AFC Ajax [Women] | 2:1 | ||||
| 9. Round | 11/12/2020 | PEC Zwolle [Women] | - | FC Twente [Women] | 1:4 | |
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| 11. Round | 05/03/2021 | ADO Den Haag [Women] | - | FC Twente [Women] | 0:0 | ||||
| 10. Round | 09/03/2021 | FC Twente [Women] | - | SBV Excelsior [Women] | 7:0 | ||||
| 12. Round | 12/03/2021 | sc Heerenveen [Women] | - | FC Twente [Women] | 2:6 | |
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| 13. Round | 21/03/2021 | FC Twente [Women] | - | vv Alkmaar [Women] | 9:0 | |
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| 14. Round | 30/03/2021 | PSV Eindhoven [Women] | - | FC Twente [Women] | 1:2 |
Netherlands