| 6. Round | 19/09/2004 | Santos Laguna | - | Jaguares Chiapas | 4:2 | ||||
| 7. Round | 25/09/2004 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 8. Round | 29/09/2004 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
| 9. Round | 02/10/2004 | Monarcas Morelia | - | Santos Laguna | 1:1 | ||||
| 12. Round | 24/10/2004 | Santos Laguna | - | Atlante | 2:1 | ||||
| 13. Round | 31/10/2004 | CF Pachuca | - | Santos Laguna | 2:1 | ||||
| 16. Round | 14/11/2004 | Santos Laguna | - | UANL Tigres | 2:1 |  |
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| 17. Round | 20/11/2004 | Cruz Azul | - | Santos Laguna | 1:0 |
Mexico