| 1. Round | 27/08/2022 | Cafetaleros de Chiapas | - | CF Pachuca II | 0:1 | ||||
| 3. Round | 08/09/2022 | Yalmakan FC | - | CF Pachuca II | 0:4 |  |
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| 4. Round | 12/09/2022 | CF Pachuca II | - | Escorpiones | 4:2 | ||||
| 5. Round | 18/09/2022 | Real de Arteaga | - | CF Pachuca II | 1:4 | ||||
| 6. Round | 23/09/2022 | CF Pachuca II | - | Deportivo Venados | 1:2 | ||||
| 7. Round | 29/09/2022 | Montañeses FC | - | CF Pachuca II | 1:3 | ||||
| 8. Round | 02/10/2022 | CF Pachuca II | - | Inter Playa | 2:0 | ||||
| 10. Round | 15/10/2022 | Deportivo Dongu | - | CF Pachuca II | 1:2 | ||||
| 11. Round | 21/10/2022 | CF Pachuca II | - | Sporting Canamy | 6:2 |
Mexico