| 1. Round | 22/08/1980 | PSV Eindhoven | - | FC Den Haag | 3:0 | ||||
| 2. Round | 26/08/1980 | AZ '67 Alkmaar | - | PSV Eindhoven | 2:0 | ||||
| 9. Round | 19/10/1980 | Willem II | - | PSV Eindhoven | 1:6 | ||||
| 10. Round | 25/10/1980 | PSV Eindhoven | - | FC Utrecht | 2:3 | ||||
| 11. Round | 31/10/1980 | Go Ahead Eagles | - | PSV Eindhoven | 1:2 |  |
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| 12. Round | 07/11/1980 | PSV Eindhoven | - | Roda JC Kerkrade | 4:1 | ||||
| 13. Round | 22/11/1980 | FC Wageningen | - | PSV Eindhoven | 0:3 | ||||
| 14. Round | 28/11/1980 | PSV Eindhoven | - | NAC Breda | 3:0 | ||||
| 15. Round | 05/12/1980 | PSV Eindhoven | - | Sparta Rotterdam | 0:0 | ||||
| 16. Round | 13/12/1980 | SBV Excelsior | - | PSV Eindhoven | 0:0 | ||||
| 17. Round | 19/12/1980 | PSV Eindhoven | - | FC Groningen | 5:0 | ||||
| 18. Round | 31/01/1981 | FC Den Haag | - | PSV Eindhoven | 1:4 | ||||
| 19. Round | 06/02/1981 | PSV Eindhoven | - | AZ '67 Alkmaar | 0:3 | ||||
| 20. Round | 13/02/1981 | PSV Eindhoven | - | PEC Zwolle | 0:1 | ||||
| 22. Round | 06/03/1981 | PSV Eindhoven | - | AFC Ajax | 3:1 | ||||
| 23. Round | 13/03/1981 | MVV | - | PSV Eindhoven | 0:2 |  |
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| 33. Round | 29/05/1981 | PSV Eindhoven | - | SBV Excelsior | 4:1 | ||||
| 34. Round | 05/06/1981 | FC Groningen | - | PSV Eindhoven | 2:0 |
Netherlands