| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 | ||||
| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 |  |
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| 8. Round | 16/09/2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Round | 20/09/2022 | Fénix | - | Defensor Sporting | 0:0 | |
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| 13. Round | 13/10/2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Round | 15/10/2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 |
Uruguay