| 1. Round | 03/07/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:3 | ||||
| 2. Round | 09/07/2022 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 3:1 |  |
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| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 | ||||
| 7. Round | 07/08/2022 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 2:2 |  |
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| 8. Round | 11/08/2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:3 | |
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| 9. Round | 18/08/2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 10. Round | 21/08/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 5:0 | |
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| 12. Round | 01/09/2022 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:2 | |
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| 13. Round | 06/09/2022 | CF América [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 14. Round | 11/09/2022 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 15. Round | 18/09/2022 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 16. Round | 23/09/2022 | FC Juárez [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 17. Round | 01/10/2022 | Atlético San Luis [U20] | - | UANL Tigres [U20] | 2:2 |
Mexico