| 6. Round | 11/08/2012 | New York RB | - | Houston Dynamo | 2:0 | ||||
| 6. Round | 20/08/2012 | Houston Dynamo | - | Columbus Crew | 2:2 | ||||
| 6. Round | 26/08/2012 | Houston Dynamo | - | Toronto FC | 1:1 | ||||
| 7. Round | 03/09/2012 | Chicago Fire | - | Houston Dynamo | 3:1 | ||||
| 7. Round | 07/09/2012 | Houston Dynamo | - | Real Salt Lake | 1:0 | ||||
| 7. Round | 15/09/2012 | Sporting Kansas City | - | Houston Dynamo | 1:1 | ||||
| 7. Round | 23/09/2012 | Philadelphia Union | - | Houston Dynamo | 3:1 | ||||
| 7. Round | 30/09/2012 | Houston Dynamo | - | New England Revolution | 2:0 |  |
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| 8. Round | 07/10/2012 | Houston Dynamo | - | Impact de Montréal | 1:1 | ||||
| 8. Round | 21/10/2012 | Houston Dynamo | - | Philadelphia Union | 3:1 |
USA