| 1. Round | 10/03/2018 | Columbus Crew | - | Impact de Montréal | 3:2 | ||||
| 1. Round | 24/03/2018 | Columbus Crew | - | D.C. United | 3:1 |  |
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| 2. Round | 29/04/2018 | Columbus Crew | - | San Jose Earthquakes | 2:1 | ||||
| 3. Round | 05/05/2018 | Seattle Sounders | - | Columbus Crew | 0:0 | ||||
| 3. Round | 13/05/2018 | Columbus Crew | - | Chicago Fire | 3:0 | ||||
| 4. Round | 03/06/2018 | Columbus Crew | - | Toronto FC | 3:3 | ||||
| 4. Round | 09/06/2018 | Columbus Crew | - | New York RB | 1:1 | ||||
| 4. Round | 24/06/2018 | Los Angeles FC | - | Columbus Crew | 2:0 | ||||
| 5. Round | 01/07/2018 | Columbus Crew | - | Real Salt Lake | 2:1 | ||||
| 5. Round | 08/07/2018 | Los Angeles Galaxy | - | Columbus Crew | 4:0 | ||||
| 6. Round | 24/08/2018 | Chicago Fire | - | Columbus Crew | 1:1 | ||||
| 7. Round | 16/09/2018 | FC Dallas | - | Columbus Crew | 0:0 |  |
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| 7. Round | 23/09/2018 | Columbus Crew | - | Colorado Rapids | 2:1 |
USA