| 6. Round | 18/09/2021 | FC Wiltz 71 | - | US Mondorf | 1:2 |  |
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| 8. Round | 26/09/2021 | Jeunesse Esch | - | US Mondorf | 1:0 | ||||
| 10. Round | 23/10/2021 | RFCU Luxemburg | - | US Mondorf | 2:1 | ||||
| 11. Round | 07/11/2021 | US Mondorf | - | Union Titus Pétange | 2:1 | |
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| 12. Round | 21/11/2021 | Progrès Niedercorn | - | US Mondorf | 3:1 | ||||
| 19. Round | 27/02/2022 | RM Hamm Benfica | - | US Mondorf | 0:1 | ||||
| 20. Round | 06/03/2022 | US Mondorf | - | FC Wiltz 71 | 2:0 | ||||
| 21. Round | 12/03/2022 | F91 Dudelange | - | US Mondorf | 2:1 | ||||
| 22. Round | 20/03/2022 | US Mondorf | - | Jeunesse Esch | 1:5 | ||||
| 23. Round | 03/04/2022 | US Hostert | - | US Mondorf | 1:1 | ||||
| 24. Round | 10/04/2022 | US Mondorf | - | RFCU Luxemburg | 2:3 |  |
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| 25. Round | 16/04/2022 | Union Titus Pétange | - | US Mondorf | 1:1 | ||||
| 26. Round | 24/04/2022 | US Mondorf | - | Progrès Niedercorn | 2:1 | ||||
| 27. Round | 01/05/2022 | US Mondorf | - | Etzella Ettelbruck | 2:1 | ||||
| 28. Round | 08/05/2022 | FC Differdange 03 | - | US Mondorf | 1:0 | ||||
| 30. Round | 22/05/2022 | CS FOLA Esch | - | US Mondorf | 1:1 |
Luxembourg