| 1. Round | 14/01/2021 | Correcaminos UAT | - | Cancún FC | 3:0 |  |
|||
| 3. Round | 28/01/2021 | Cancún FC | - | Atlético Morelia | 1:2 | ||||
| 4. Round | 04/02/2021 | TM Fútbol Club | - | Cancún FC | 1:1 | ||||
| 6. Round | 17/02/2021 | Club Celaya | - | Cancún FC | 4:0 | |
|||
| 7. Round | 25/02/2021 | Cancún FC | - | Tapatío | 1:0 | ||||
| 8. Round | 03/03/2021 | Mineros de Zacatecas | - | Cancún FC | 2:0 |  |
|||
| 11. Round | 24/03/2021 | Alebrijes de Oaxaca | - | Cancún FC | 0:0 | ||||
| 12. Round | 28/03/2021 | Cancún FC | - | Tepatitlán | 5:1 | ||||
| 13. Round | 01/04/2021 | Coyotes de Tlaxcala | - | Cancún FC | 1:0 | ||||
| 14. Round | 08/04/2021 | Cancún FC | - | Leones Negros | 2:0 | |
|||
| 15. Round | 15/04/2021 | Pumas Tabasco | - | Cancún FC | 1:2 |
Mexico