| 1. Round | 08/08/2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 | ||||
| 2. Round | 11/08/2020 | Slovan Bratislava | - | MFK Zemplín Michalovce | 5:0 |  |
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| 3. Round | 15/08/2020 | FK Senica | - | MFK Zemplín Michalovce | 3:0 | |
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| 4. Round | 25/08/2020 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 |  |
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| 5. Round | 30/08/2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 | ||||
| 6. Round | 12/09/2020 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 | |
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| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 | |
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| 8. Round | 26/09/2020 | MFK Zemplín Michalovce | - | FK Pohronie | 2:0 | ||||
| 9. Round | 03/10/2020 | ŠKF Sereď | - | MFK Zemplín Michalovce | 1:1 |  |
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| 11. Round | 24/10/2020 | FC Nitra | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Round | 31/10/2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 14. Round | 21/11/2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 16. Round | 05/12/2020 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:1 | ||||
| 17. Round | 13/12/2020 | AS Trenčín | - | MFK Zemplín Michalovce | 2:2 | |
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| 22. Round | 06/03/2021 | MFK Zemplín Michalovce | - | FC Nitra | 1:0 |
Panama