| 1. Round | 09/07/2016 | Libertad | - | River Plate | 1:1 | ||||
| 2. Round | 16/07/2016 | River Plate | - | General Díaz | 0:0 |  |
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| 3. Round | 20/07/2016 | Guaraní | - | River Plate | 2:0 | ||||
| 5. Round | 01/08/2016 | Club Rubio Ñu | - | River Plate | 5:1 | ||||
| 7. Round | 12/08/2016 | Sportivo Luqueño | - | River Plate | 1:0 | |
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| 8. Round | 19/08/2016 | Deportivo Capiatá | - | River Plate | 0:3 | |
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| 9. Round | 29/08/2016 | River Plate | - | Cerro Porteño | 2:3 |
Paraguay