| 8. Round | 19/02/2022 | Jaguares de Córdoba | - | Millonarios | 1:2 | ||||
| 9. Round | 27/02/2022 | Millonarios | - | Cortuluá | 1:0 |  |
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| 10. Round | 06/03/2022 | Santa Fe | - | Millonarios | 0:3 | ||||
| 11. Round | 19/03/2022 | Millonarios | - | Once Caldas | 1:0 | ||||
| 12. Round | 24/03/2022 | Independiente Medellín | - | Millonarios | 1:0 | ||||
| 13. Round | 31/03/2022 | Millonarios | - | Atlético Junior | 1:0 |  |
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| 14. Round | 03/04/2022 | América de Cali | - | Millonarios | 3:2 | |
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| 15. Round | 09/04/2022 | Millonarios | - | La Equidad | 2:1 | ||||
| 16. Round | 17/04/2022 | Deportivo Pereira | - | Millonarios | 1:0 | ||||
| 19. Round | 09/05/2022 | Millonarios | - | Deportes Tolima | 0:0 |
Venezuela