| 3. Round | 20/02/2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 6. Round | 13/03/2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
| 7. Round | 20/03/2022 | Club Olimpia | - | Sportivo Ameliano | 0:2 | ||||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 09/04/2022 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 10. Round | 16/04/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:0 |  |
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| 11. Round | 20/04/2022 | Club Olimpia | - | Guaraní | 1:0 | ||||
| 12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
| 13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
| 19. Round | 19/06/2022 | Club Olimpia | - | Resistencia SC | 6:1 | |
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| 20. Round | 23/06/2022 | Club Nacional | - | Club Olimpia | 1:1 |
Paraguay
Spain