| 4. Round | 08/02/2016 | Libertad | - | River Plate | 3:1 | ||||
| 5. Round | 13/02/2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Round | 20/02/2016 | Club Nacional | - | River Plate | 0:0 | ||||
| 7. Round | 27/02/2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Round | 02/03/2016 | Deportivo Capiatá | - | River Plate | 1:1 |  |
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| 13. Round | 06/04/2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Round | 11/04/2016 | Sportivo Luqueño | - | River Plate | 2:0 | |
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| 15. Round | 17/04/2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Round | 21/04/2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Round | 25/04/2016 | River Plate | - | Club Nacional | 1:3 |  |
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| 21. Round | 14/05/2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Round | 21/05/2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay