| 1. Round | 26/01/2025 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 2. Round | 30/01/2025 | Guaraní | - | General Caballero DJLM | 2:1 | ||||
| 3. Round | 03/02/2025 | 2 de Mayo | - | Guaraní | 0:2 |  |
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| 4. Round | 09/02/2025 | Guaraní | - | Libertad | 0:1 | ||||
| 6. Round | 21/02/2025 | Guaraní | - | Deportivo Recoleta | 1:3 | ||||
| 7. Round | 02/03/2025 | Cerro Porteño | - | Guaraní | 0:1 | ||||
| 9. Round | 14/03/2025 | Guaraní | - | Atlético Tembetary | 0:0 | ||||
| 11. Round | 27/03/2025 | Guaraní | - | Sportivo Trinidense | 1:3 | ||||
| 12. Round | 06/04/2025 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 13. Round | 14/04/2025 | General Caballero DJLM | - | Guaraní | 0:0 | ||||
| 15. Round | 19/04/2025 | Libertad | - | Guaraní | 1:3 |  |
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| 16. Round | 26/04/2025 | Guaraní | - | Club Nacional | 2:1 | ||||
| 17. Round | 03/05/2025 | Deportivo Recoleta | - | Guaraní | 0:3 | |
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| 18. Round | 10/05/2025 | Guaraní | - | Cerro Porteño | 0:2 |
Paraguay