| 1. Round | 14/08/2021 | Fortuna Sittard | - | FC Twente | 2:1 | ||||
| 6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
| 7. Round | 25/09/2021 | Vitesse | - | Fortuna Sittard | 1:1 | ||||
| 8. Round | 02/10/2021 | Fortuna Sittard | - | NEC Nijmegen | 1:3 | ||||
| 2. Round | 02/12/2021 | AZ Alkmaar | - | Fortuna Sittard | 2:1 |  |
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| 18. Round | 22/12/2021 | AFC Ajax | - | Fortuna Sittard | 5:0 | ||||
| 27. Round | 20/03/2022 | PSV Eindhoven | - | Fortuna Sittard | 5:0 |
Netherlands
Congo DR