| 1. Round | 18/07/2021 | FK Znamya Noginsk | - | FK Strogino Moskva | 3:1 | ||||
| 2. Round | 24/07/2021 | FK Strogino Moskva | - | FK Saransk | 1:1 | ||||
| 4. Round | 07/08/2021 | FK Strogino Moskva | - | FK Kolomna | 4:0 | ||||
| 17. Round | 19/10/2021 | FK Strogino Moskva | - | Metallurg Vidnoye | 5:0 | ||||
| 18. Round | 25/10/2021 | FK Saturn | - | FK Strogino Moskva | 1:2 | ||||
| 19. Round | 31/10/2021 | FK Strogino Moskva | - | FK Khimki 2 | 1:0 | ||||
| 21. Round | 10/11/2021 | FK Strogino Moskva | - | SKA-Khabarovsk 2 | 0:3 |
Russia