| 5. Round | 20/09/2021 | FC Barcelona | - | Granada CF | 1:1 | ||||
| 6. Round | 23/09/2021 | Cádiz CF | - | FC Barcelona | 0:0 | ||||
| 7. Round | 26/09/2021 | FC Barcelona | - | Levante UD | 3:0 | ||||
| 8. Round | 02/10/2021 | Atlético Madrid | - | FC Barcelona | 2:0 | ||||
| 12. Round | 30/10/2021 | FC Barcelona | - | CD Alavés | 1:1 | ||||
| 13. Round | 06/11/2021 | RC Celta | - | FC Barcelona | 3:3 | ||||
| 14. Round | 20/11/2021 | FC Barcelona | - | Espanyol Barcelona | 1:0 | ||||
| 16. Round | 04/12/2021 | FC Barcelona | - | Real Betis | 0:1 | ||||
| 18. Round | 18/12/2021 | FC Barcelona | - | Elche CF | 3:2 | ||||
| 19. Round | 02/01/2022 | RCD Mallorca | - | FC Barcelona | 0:1 | ||||
| 28. Round | 13/03/2022 | FC Barcelona | - | CA Osasuna | 4:0 |  |
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| 35. Round | 07/05/2022 | Real Betis | - | FC Barcelona | 1:2 | ||||
| 36. Round | 10/05/2022 | FC Barcelona | - | RC Celta | 3:1 | ||||
| 37. Round | 15/05/2022 | Getafe CF | - | FC Barcelona | 0:0 | ||||
| 38. Round | 22/05/2022 | FC Barcelona | - | Villarreal CF | 0:2 |
Spain