| 1. Round | 13/09/2020 | FC Emmen | - | VVV-Venlo | 3:5 |  |
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| 2. Round | 19/09/2020 | PSV Eindhoven | - | FC Emmen | 2:1 | ||||
| 3. Round | 27/09/2020 | FC Emmen | - | Willem II | 1:1 | ||||
| 5. Round | 18/10/2020 | FC Emmen | - | Fortuna Sittard | 2:2 | ||||
| 18. Round | 23/01/2021 | ADO Den Haag | - | FC Emmen | 0:0 | ||||
| 19. Round | 26/01/2021 | FC Emmen | - | PSV Eindhoven | 0:2 | ||||
| 21. Round | 06/02/2021 | FC Emmen | - | AZ Alkmaar | 0:1 | ||||
| 27. Round | 20/03/2021 | Feyenoord | - | FC Emmen | 1:1 | ||||
| 29. Round | 10/04/2021 | Fortuna Sittard | - | FC Emmen | 1:3 | ||||
| 30. Round | 25/04/2021 | FC Emmen | - | Heracles Almelo | 3:1 | ||||
| 31. Round | 02/05/2021 | AFC Ajax | - | FC Emmen | 4:0 | ||||
| 33. Round | 13/05/2021 | FC Emmen | - | sc Heerenveen | 3:1 | ||||
| 34. Round | 16/05/2021 | VVV-Venlo | - | FC Emmen | 0:4 |
Netherlands