| 1. Round | 17/07/2010 | Tacuary | - | Club Rubio Ñu | 0:0 | ||||
| 2. Round | 24/07/2010 | Club Rubio Ñu | - | Sport Colombia | 1:0 | ||||
| 7. Round | 29/08/2010 | Club Rubio Ñu | - | Cerro Porteño | 1:2 | ||||
| 8. Round | 04/09/2010 | Club Nacional | - | Club Rubio Ñu | 0:0 |  |
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| 9. Round | 12/09/2010 | Club Rubio Ñu | - | Sol de América | 2:1 |  |
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| 10. Round | 19/09/2010 | Sportivo Trinidense | - | Club Rubio Ñu | 1:2 | |
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| 11. Round | 27/09/2010 | Guaraní | - | Club Rubio Ñu | 1:2 | |
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| 12. Round | 02/10/2010 | Club Rubio Ñu | - | Tacuary | 1:2 |
Argentina