| 4. Round | 15/05/2022 | Houston Dynamo | - | Nashville SC | 2:0 | ||||
| 4. Round | 19/05/2022 | Houston Dynamo | - | Seattle Sounders | 0:1 | ||||
| 4. Round | 23/05/2022 | Los Angeles Galaxy | - | Houston Dynamo | 0:3 |  |
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| 4. Round | 29/05/2022 | Real Salt Lake | - | Houston Dynamo | 3:0 | |
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| 5. Round | 19/06/2022 | Orlando City | - | Houston Dynamo | 2:1 | |
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| 5. Round | 26/06/2022 | Houston Dynamo | - | Chicago Fire | 2:0 | ||||
| 6. Round | 10/07/2022 | Houston Dynamo | - | FC Dallas | 2:2 | ||||
| 7. Round | 01/09/2022 | Houston Dynamo | - | Los Angeles FC | 2:1 |
USA
Mexico