| 2. Round | 15/01/2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 2:2 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 | ||||
| 9. Round | 05/03/2022 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 2:3 | ||||
| 10. Round | 12/03/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 11. Round | 19/03/2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 12. Round | 26/03/2022 | Club León [U16] | - | Deportivo Guadalajara [U16] | 0:3 | ||||
| 15. Round | 30/03/2022 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 5:1 | ||||
| 14. Round | 09/04/2022 | Mazatlán FC [U16] | - | Deportivo Guadalajara [U16] | 1:2 | ||||
| 16. Round | 23/04/2022 | Atlas Guadalajara [U16] | - | Deportivo Guadalajara [U16] | 2:2 |
Mexico
Germany