| 4. Round | 21/07/2024 | FC Juárez | - | CF América | 1:2 |  |
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| 6. Round | 01/09/2024 | Cruz Azul | - | CF América | 4:1 | ||||
| 7. Round | 15/09/2024 | CF América | - | Deportivo Guadalajara | 1:0 | ||||
| 8. Round | 18/09/2024 | CF América | - | Atlas Guadalajara | 3:0 | |
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| 9. Round | 22/09/2024 | Club Necaxa | - | CF América | 1:1 | |
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| 10. Round | 30/09/2024 | CF América | - | Pumas UNAM | 0:1 | |
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| 11. Round | 06/10/2024 | Club León | - | CF América | 1:1 | |
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| 13. Round | 24/10/2024 | Club Tijuana | - | CF América | 2:2 | |
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| 15. Round | 02/11/2024 | Mazatlán FC | - | CF América | 0:5 | |
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| 16. Round | 07/11/2024 | CF América | - | CF Pachuca | 2:1 | |
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| 17. Round | 10/11/2024 | Deportivo Toluca | - | CF América | 4:0 |
Uruguay