| 1. Round | 07/01/2023 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
| 2. Round | 14/01/2023 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 1:2 | ||||
| 3. Round | 21/01/2023 | Santos Laguna [U16] | - | CF Monterrey [U16] | 2:0 |  |
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| 10. Round | 11/03/2023 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 3:2 |  |
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| 12. Round | 25/03/2023 | CF Monterrey [U16] | - | Santos Laguna [U16] | 1:2 | ||||
| 13. Round | 30/03/2023 | Santos Laguna [U16] | - | UANL Tigres [U16] | 1:0 | ||||
| 14. Round | 08/04/2023 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 |  |
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| 17. Round | 29/04/2023 | Club León [U16] | - | Santos Laguna [U16] | 3:2 | ||||
| 18. Round | 06/05/2023 | Santos Laguna [U16] | - | Club Tijuana [U16] | 1:0 |
Mexico