| 1. Round | 27/01/2023 | Libertad | - | Guaraní | 1:0 | ||||
| 2. Round | 03/02/2023 | Guaraní | - | Sportivo Ameliano | 2:2 | ||||
| 3. Round | 11/02/2023 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 4. Round | 17/02/2023 | Resistencia SC | - | Guaraní | 0:4 | ||||
| 5. Round | 25/02/2023 | Guaraní | - | Sportivo Luqueño | 3:1 | ||||
| 7. Round | 14/03/2023 | Guaraní | - | Tacuary | 1:0 | ||||
| 8. Round | 19/03/2023 | Sportivo Trinidense | - | Guaraní | 1:1 | ||||
| 10. Round | 01/04/2023 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 11. Round | 11/04/2023 | Guaraní | - | General Caballero DJLM | 3:1 |  |
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| 12. Round | 14/04/2023 | Guaraní | - | Libertad | 0:0 | ||||
| 14. Round | 25/04/2023 | Guaraní | - | Cerro Porteño | 0:3 | ||||
| 15. Round | 29/04/2023 | Guaraní | - | Resistencia SC | 1:0 | ||||
| 21. Round | 03/06/2023 | Guaraní | - | Club Olimpia | 1:2 | ||||
| 22. Round | 10/06/2023 | General Caballero DJLM | - | Guaraní | 0:0 |
Paraguay